Period and timeless mRNA Splicing Profiles under Natural Conditions in Drosophila melanogaster.
Montelli S, Mazzotta G, Vanin S, Caccin L, Corrà S, De Pittà C, Boothroyd C, Green EW, Kyriacou CP, Costa . Journal of biological rhythms Abstract Previous analysis of Drosophila circadian behavior under natural conditions has revealed a number of novel and unexpected features. Here we focus on the oscillations of per and tim mRNAs […]
Assessment of 6-sulfatoxymelatonin rhythms and melatonin response to light in disease states: lessons from cirrhosis.
Montagnese S, Middleton B, Corrias M, Mani AR, Skene DJ, Morgan MY. Chronobiology International Abstract Circadian rhythmicity and non-visual sensitivity to light can be assessed, in healthy subjects, by measuring the rhythm of the urinary melatonin metabolite 6-sulphatoxymelatonin (aMT6s) and by determining the response of plasma melatonin to nocturnal retinal light exposure, respectively. However, the […]
Nucleotide excision repair efficiency in quiescent human fibroblasts is modulated by circadian clock.
Bee L, Marini S, Pontarin G, Ferraro P, Costa R, Albrecht U, Celotti L. Nucleic Acids Research Abstract The efficiency of Nucleotide Excision Repair (NER)process is crucial for maintaining genomic integrity because in many organisms, including humans, it represents the only system able to repair a wide range of DNA damage. The aim of the […]
Acute hyperammonaemia induces a sustained decrease in vigilance, which is modulated by caffeine.
Casula EP, Bisiacchi PS, Corrias M, Schiff S, Merkel C, Amodio P, Montagnese S. Metabolic Brain Disease Abstract Hyperammonaemia is observed after prolonged, intense exercise, or in patients with hepatic failure. In the latter, it is associated with a set of neurological and psychiatric abnormalities termed hepatic encephalopathy. THE AIMS OF OUR STUDY WERE: 1. […]
Sleep and circadian rhythms in hospitalized patients with decompensated cirrhosis: effect of light therapy.
De Rui M, Middleton B, Sticca A, Gatta A, Amodio P, Skene DJ, Montagnese S. Neurochemistry Research Abstract Patients with liver cirrhosis often exhibit sleep-wake abnormalities, which are, at least to some extent, circadian in origin. A relatively novel non-pharmacological approach to circadian disruption is appropriately timed bright light therapy. The aims of this pilot […]