Aminergic Signaling Controls Ovarian Dormancy in Drosophila
Andreatta G, Kyriacou CP, Flatt T, Costa R Scientific Reports 2018 In response to adverse environmental conditions many organisms from nematodes to mammals deploy a dormancy strategy, causing states of developmental or reproductive arrest that enhance somatic maintenance and survival ability at the expense of growth or reproduction. Dormancy regulation has been studied in C. […]
Diapause in Drosophila melanogaster – photoperiodicity, cold tolerance and metabolites
Anduaga AM, Nagy D, Costa R, Kyriacou CP. Journal of Insect Physiology 2018 Unlike many insects where photoperiod per se induces diapause, reproductive arrest in Drosophila melanogaster adult females is observed at colder temperatures and can be enhanced by shorter photoperiods. Traditional experimental protocols raise flies at 25°C from the larval stage and then the adults are placed at […]
Neuropsychiatric performance and treatment of hepatitis C with direct-acting antivirals: a prospective study
Volpato S, Montagnese S, Zanetto A, Turco M, De Rui M, Ferrarese A, Amodio P, Germani G, Senzolo M, Gambato M, Russo FP, Burra P. BMJ open gastroenterology 2017 BACKGROUND:Since direct-acting antivirals (DAAs) have been approved for the treatment of hepatitis C virus (HCV) infection, a small series of patients with new-onset neuropsychiatric alterations have been referred to us. We therefore set out to study neuropsychiatricfunction in […]
Functional characterization of the circadian clock in the Antarctic krill, Euphausia superba
Biscontin A, Wallach T, Sales G, Grudziecki A, Janke L, Sartori E, Bertolucci C, Mazzotta G, De Pittà C, Meyer B, Kramer A, Costa R. Scientific Reports 2017 Antarctic krill (Euphausia superba) is a key species in Southern Ocean ecosystem where it plays a central role in the Antarctic food web. Available information supports the existence of an endogenous timing […]
Inverse European Latitudinal Cline at the timeless Locus of Drosophila melanogaster Reveals Selection on a Clock Gene: Population Genetics of ls-tim.
Zonato V, Vanin S, Costa R, Tauber E, Kyriacou CP. J Biol Rhythms. 2017 The spread of adaptive genetic variants in populations is a cornerstone of evolutionary theory but with relatively few biologically well-understood examples. Previous work on the ls-tim variant of timeless, which encodes the light-sensitive circadian regulator in Drosophila melanogaster, suggests that it may […]