Inhibition of the deubiquitinase USP8 corrects a Drosophila PINK1 model of mitochondria dysfunction
Von Stockum S, Sanchez-Martinez A, Corrà S, Chakraborty J, Marchesan E, Locatello L, Da-Rè C, Cusumano P, Caicci F, Ferrari V, Costa R, Bubacco L, Rasotto MB, Szabo I, Whitworth AJ, Scorrano L, Ziviani E Life Science Alliance Aberrant mitochondrial dynamics disrupts mitochondrial function and contributes to disease conditions. A targeted RNA interference screen for […]
The role of astrocytes in generating circadian rhythmicity in health and disease
Costa R, Montagnese S Journal of Neurochemistry Evidence is accumulating that the mammalian circadian clock system is considerably more complex than previously believed, also in terms of the cell types that actually contribute to generating the oscillation within the master clock, in the suprachiasmatic nuclei of the hypothalamus. Here we review the evidence that has […]
Sleep, Circadian Rhythmicity and Response to Chronotherapy in University Students: Tips from Chronobiology Practicals
Montagnese S, Zarantonello L, Formentin C, Zancato C, Bonetto M B, Biscontin A, Cusumano P, Costa R (2021) Journal of Circadian Rhythms Chronobiology is not routinely taught to biology or medical students in most European countries. Here we present the results of the chronobiology practicals of a group of students of the University of Padova, with a […]
Gufi o allodole? Cosa sono e come funzionano gli orologi circadiani.
Costa R, Montagnese S L’orologio circadiano, che regola i ritmi sonno-veglia e altri aspetti della nostra fisiologia, si sincronizza con l’ambiente naturale che ci circonda, soprattutto per mezzo della luce del Sole. Tuttavia le nostre abitudini di vita, condizionate dall’orologio sociale, spesso confliggono con i ritmi dettati dall’orologio circadiano. Questo favorisce l’insorgenza di malattie, anche […]
The µMCTQ: An Ultra-Short Version of the Munich ChronoType Questionnaire.
Ghotbi N, Pilz LK, Winnebeck EC, Vetter C, Zerbini G, Lenssen D, Frighetto G, Salamanca M, Costa R, Montagnese S, Roenneberg T Journal of Biological Rhythms Individuals vary in how their circadian system synchronizes with the cyclic environment (zeitgeber). Assessing these differences in “phase of entrainment”-often referred to as chronotype-is an important procedure in laboratory […]