Granados-Fuentes D, Cho K, Patti GJ, Costa R, Herzog E D, Montagnese S Liver Int Patients with cirrhosis exhibit features of circadian disruption. Hyperammonaemia has been suggested to impair both homeostatic and circadian sleep regulation. Here, we tested if hyperammonaemia directly disrupts circadian rhythm generation in the central pacemaker, the suprachiasmatic nuclei (SCN) of the […]
Häussinger D, Dhiman RK, Felipo V, Görg B, Jalan R, Kircheis G, Merli M, Montagnese S, Romero-Gomez M, Schnitzler A, Taylor-Robinson SD, Vilstrup H Nat Rev Dis Primers Illustrated summary of the article Full text
Montagnese S, Gómez MR, Larsen FS, Shawcross D, Thabut D, Vilstrup HA V, Weissenborn K, Rautou PE, Corresponding author: European Association for the Study of the Liver (EASL) Journal of Hepatology The EASL Clinical Practice Guidelines (CPGs) on the management of hepatic encephalopathy (HE) present evidence-based answers to a set of relevant questions (where possible, […]
Mangini C, Zarantonello L, Formentin C, Giusti G, Angeli P, Montagnese S Digestive and Liver Disease Objectives Few data on hepatic encephalopathy (HE) over time are available, thus our aim was to study its evolution in patients with varying degree of HE on first assessment. Methods Eighty-six patients with cirrhosis (age = 58 ± 11 […]
Mangini C, Montagnese S J Clin Med Hepatic encephalopathy (HE) is a common complication of advanced liver disease which has profound implications in terms of the patients’ ability to fulfil their family and social roles, to drive and to provide for themselves. Recurrent and persistent HE is still a serious management challenge, translating into a […]
Ponziani FR, Aghemo A, Cabibbo G, Masarone M, Montagnese S, Petta S, Russo FP, Lai Q; AISF COVID-19 survey group Liver International Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has severely limited the clinical activity of most hospitals around the world. A previous survey of the Italian Association for the Study of the Liver (AISF) […]
Garcia-Pagan JC, Francoz C, Montagnese S, Senzolo M, Mookerjee RP Journal of Hepatology Along with a growing understanding of the pathophysiology of cirrhosis and its complications, new therapies and management strategies have emerged in recent years. Many of these advances have helped inform the current EASL clinical practice guidelines1 on the management of some of […]
Russo F P, Piano S, Bruno R, Burra P, Puoti M, Masarone M, Montagnese S, Ponziani F R, Petta S, Aghemo A, Italian Association for the Study of the Liver Digestive and Liver Disease The vaccination campaign against Sars-CoV-2 commenced in Italy at the end of December 2020. The first ones to receive the immunization […]
Montagnese S, Lauridsen M, Vilstrup H, Zarantonello L, Lakner G, Fitilev S, Zupanets I, Kozlova I, Bunkova E, Tomasiewicz K, Berglund JE, Rorsman F, Hagström H, Kechagias S, Ocklind CE, Mauney J, Thunarf F, Mokhatarani M, Bäckström T, Doverskog M, Lins LE, Månsson M, Samuelson P, Nilsson D, Schalling M, Johansson M, Arlander E, Scharschmidt […]
Montagnese S, Bajaj JS Drugs Hepatic encephalopathy (HE) has a major impact on health-related quality of life (HRQOL) in patients, which has clinical and psychosocial consequences. HRQOL in cirrhosis has been measured by generic and liver-specific instruments, with most studies indicating a negative impact of HE. HRQOL abnormalities span daily functioning, sleep–wake cycle changes, and […]
