Andreatta G, Kyriacou CP, Flatt T, Costa R Scientific Reports 2018 In response to adverse environmental conditions many organisms from nematodes to mammals deploy a dormancy strategy, causing states of developmental or reproductive arrest that enhance somatic maintenance and survival ability at the expense of growth or reproduction. Dormancy regulation has been studied in C. […]
Anduaga AM, Nagy D, Costa R, Kyriacou CP. Journal of Insect Physiology 2018 Unlike many insects where photoperiod per se induces diapause, reproductive arrest in Drosophila melanogaster adult females is observed at colder temperatures and can be enhanced by shorter photoperiods. Traditional experimental protocols raise flies at 25°C from the larval stage and then the adults are placed at […]
Volpato S, Montagnese S, Zanetto A, Turco M, De Rui M, Ferrarese A, Amodio P, Germani G, Senzolo M, Gambato M, Russo FP, Burra P. BMJ open gastroenterology 2017 BACKGROUND:Since direct-acting antivirals (DAAs) have been approved for the treatment of hepatitis C virus (HCV) infection, a small series of patients with new-onset neuropsychiatric alterations have been referred to us. We therefore set out to study neuropsychiatricfunction in […]
Biscontin A, Wallach T, Sales G, Grudziecki A, Janke L, Sartori E, Bertolucci C, Mazzotta G, De Pittà C, Meyer B, Kramer A, Costa R. Scientific Reports 2017 Antarctic krill (Euphausia superba) is a key species in Southern Ocean ecosystem where it plays a central role in the Antarctic food web. Available information supports the existence of an endogenous timing […]
Zonato V, Vanin S, Costa R, Tauber E, Kyriacou CP. J Biol Rhythms. 2017 The spread of adaptive genetic variants in populations is a cornerstone of evolutionary theory but with relatively few biologically well-understood examples. Previous work on the ls-tim variant of timeless, which encodes the light-sensitive circadian regulator in Drosophila melanogaster, suggests that it may […]
Altered distal-proximal temperature gradient as a possible explanation for sleep-wake disturbances in cirrhotic patients. Liver International 2017 Weiss N, Attali V, Bouzbib C, Thabut D
Marini S, Santangeli O, Saarelainen P, Middleton B, Chowdhury N, Skene DJ, Costa R,Porkka-Heiskanen T, Montagnese S Frontiers in Physiology (section Integrative Physiology) Patients with liver cirrhosis can develop hyperammonemia and hepatic encephalopathy (HE), accompanied by pronounced daytime sleepiness. Previous studies with healthy volunteers show that experimental increase in blood ammonium levels increases sleepiness and slows […]
Turco M, Biscontin A, Corrias M, Caccin L, Bano M, Chiaromanni F, Salamanca M, Mattei D, Salvoro C, Mazzotta G, De Pittà C, Middleton M, Skene D, Montagnese S, Costa R. Scientific reports PER3 gene polymorphisms have been associated with differences in human sleep-wake phenotypes, and sensitivity to light. The aims of this study were […]
Garrido M, Saccardo D, De Rui M, Vettore E, Verardo A, Carraro P, Di Vitofrancesco N, Mani AR, Angeli P, Bolognesi M, Montagnese S. Liver International BACKGROUND & AIMS: Sleep preparation/onset are associated with peripheral vasodilatation and a decrease in body temperature. The hyperdynamic syndrome exhibited by patients with cirrhosis may impinge on sleep preparation, […]
Longato E, Garrido M, Saccardo D, Montesinos Guevara C, Mani A, Bolognesi M, Amodio P, Facchinetti A, Sparacino G, Montagnese S. PlosOne A popular method to estimate proximal/distal temperature (TPROX and TDIST) consists in calculating a weighted average of nine wireless sensors placed on pre-defined skin locations. Specifically, TPROX is derived from five sensors placed […]
